Scalable Agitated Baffle Reactor
Combines the benefits of batch and flow:
Flexibility of batch. SABRe is multipurpose, and scalable. All the batch engineering and applies.
Performance of flow. SABRe heat and mass transfer is close to that of tubular and chip reactors.
Result: higher product quality, faster development, higher throughput.
Best in class performance
Proven in the liquid-liquid enzymatic esterification comparing batch, chip, and other agitated continuous reactors!
To move rapidly from laboratory, to pilot, to production scale.
- Rapid scalability
- Speeding-up complex and exothermic process
- Process intensification – high throughput at low cost
SABRe: series of continuous stirred tanks (CSTRs) reimagined: simple, multi-purpose, scalable
Each chamber is a stirred tank
Mixing independent on flow rates
Reagents could be added or removed
That enables simple & efficient reaction cascades
Precise contol of residence time
Several temperature zones
Rapid heat transfer with standard circulators
Modular design for many applications
Designed to work as a drop in replacement for jacketed batch reactors, SABRe is compatible with major pumps, chillers, heaters and overhead stirrers. You don’t have to invest in a new suite of equipment to explore continuous manufacture.
One pressure vessel provides
- several reactor volumes
- various impellers
- various inlet/outlet points
- various number of chambers
- different baffle geometry
… all with a removable insert
Rapid scale-up of precision chemical manufacturing
SABRe provides unrivalled reaction control, even at long residence times and large scale.
Mixing independent on pumping rates enables consistent, controllable, and predictable mass transfer performance.
Several jacket options enable high heat transfer rates for handling hazardous and exothermic reactions.
The SABRe system is offered in 3 standard sizes for lab, pilot and production scale, allowing the user a clear route to scale up without sacrificing yield, purity or energy efficiency.
Saves materials, energy and labour costs
Example process -aromatic hydrogenation of cresol
Savings are proven independently
(similar reactor concept): Machefer, S., Falk, L., & de Panthou, F. (2013). DOI: 10.1016/j.cep.2012.06.005
Predictable performance fully characterised
Steven’s oxidation with Vapourtec
1.4 kg/day multiphase oxidation obtained integrating SABRe system with Vapourtec’s R-Series
Consistent oil-in-water emulsions in continuous flow
Using a continuous multi-CSTR system allowed us to make droplets 2.5 times more uniform compared to a batch reactor
How to calculate heat transfer in continuous flow applications
Continuous flow (such as micro-reactors) are superior for exothermic reactions. How do you compute the thermal performance of a reactor?
Maximising interfacial gas-liquid area with Scalable Agitated Baffle Reactor (SABRe)
How the SABRE system provides large gas-liquid area to maximise the reaction throughput and selectivity.
Comparison of continuous reactors in enzymatic esterification
We showed superior performance of SABRe in the enzymatic (liquid-liquid) esterification.
How residence time affects product quality in flow chemistry
How residence time is vital for throughput and product quality.
Gas-liquid mass transfer (kLa) in scalable flow chemistry. Scalable Agitated Baffle Reactor (SABRe)
The gas-liquid mass transfer coefficient is a key parameter in multiphase reactions. We studied it for the SABRe.
Residence time distribution in the Scalable Agitated Baffle Reactor (SABRe)
The SABRe provides precise residence time control.
|Primary Wetted Material|
316 Stainless or C276 Hastelloy
|Secondary Wetted Material||PTFE / FFKM|
Lab: 20 – 120 mL
Download specifications (pdf)
Specifications: size, mass, operating parameters
Lab system 100 mL
20 or 120 mL with various inserts
-190 to 200 C
Pressure (material dependent)
Standard: vacuum to 20 bar
Bespoke: up to 100 bar
30 s to 5 hr in continuous
Could be use in batch-mode!
10 to 1500 RPM
Reactor & Stand 300 x 300 x 850 mm
Skid (turnkey system) 450 x 680 x 1910 mm
Reactor & Stand 15 kg
Skid 35 kg
Swagelok 1/8” or 1/4″ in. reagent port
Swagelok 1/8” or 1/4″ in. reagent port
M16x1 or 12mm pipe for circulator
almost any overhead stirrer, such as IKA
any liquid pumps such as HPLC or peristaltic
Pilot system: 1L
Piloting starts in 2022. There are still 2 opportunities to join the piloting programme and benefit from scalable & multipurpose continuous processing.
Pilot system: 10L
Piloting in progress. There are still 2 opportunities to join the piloting programme and benefit from scalable & multipurpose continuous processing.